TPO and malaria: The site-directed design of peptide mimetics from amide-reduced pseudopeptides using native sequence encoded 4044 (shown to be poorly immunogenic and non-protection inducing against malaria in previous studies and the present one) led to obtaining two powerful pseudopeptides which were able to induce a humoral immune response mediated by antibodies specifically recognizing two groups of MSA-2 antigen-derived proteins.