VCP and amyotrophic lateral sclerosis: Moreover, both FTD and ALS can be caused by mutations in the same gene, such as those encoding valosin-containing protein (VCP) [22, 46], charged multivesicular body protein 2B (CHMP2B) [11, 42], ubiquilin 2 (UBQLN2) [14], and chromosome 9 open reading frame 72 (C9ORF72) [12, 39].