The consistency of results from our non-Hispanic White population with those from European White populations, taken together with the consistency of observed effects of loci in ARID5B, and to a lesser extent CEBPE, between Hispanic and non-Hispanic White populations in our study, provides compelling support that these loci are indeed involved in risk of childhood ALL, particularly BCP high-hyperdiploid ALL. The gene discussed is ARID5B; the disease is acute lymphoblastic leukemia.