CDKN2A and acute lymphoblastic leukemia: However, one CDKN2A SNP, rs3731217, showed a suggestive association with total ALL [OR 0.71 (0.49–1.03)] that gained strength and reached significance when restricted first to BCP ALL [OR 0.66 (0.44–0.99)] and then to BCP high-hyperdiploid ALL [OR 0.46 (0.22–0.95)].