Additionally, ALS-associated TDP-43 mutants and FUS/TLS mutants were colocalized with NEAT1_2 lncRNA as frequently as WT TDP-43 and WT FUS/TLS (TDP-43A315T: 93.3 ± 12.7%, TDP-43A382T: 98.0 ± 8.2%, FUS/TLSR514S: 95.8 ± 9.3%, and FUS/TLSP525L: 98.4 ± 5.8%; Additional file 1: Figure S1B, C). This evidence concerns the gene TARDBP and amyotrophic lateral sclerosis.