CACNA2D3 and neoplasm: Since both the r3 and r4 subgroups are previously found to show unfavourable outcome and poor survival [12], and the CACNA2D3 gene is located in the 3p21.1- locus commonly deleted in many NB tumours, this encouraged us to further screen the SAMintersect gene lists for other conceivable and previously reported tumour suppressor (TS) candidate genes.