Since both the r3 and r4 subgroups are previously found to show unfavourable outcome and poor survival [12], and the CACNA2D3 gene is located in the 3p21.1- locus commonly deleted in many NB tumours, this encouraged us to further screen the SAMintersect gene lists for other conceivable and previously reported tumour suppressor (TS) candidate genes. This evidence concerns the gene CACNA2D3 and neuroblastoma.