Multiple factors such as disuse atrophy due to joint pain and proinflammatory cytokines such as TNF-α, IL-1β, and IL-6 are considered attributable to rheumatoid cachexia; however, there have been few reports regarding histopathology of muscle in RA patients and the cause of rheumatoid cachexia is not completely understood yet. This evidence concerns the gene IL6 and rheumatoid arthritis.