A role of CD54 in neutrophil migration is unlikely, given our current state of knowledge, as it has no known ligands on endothelial cells, but it has been reported up-regulated on peripheral blood neutrophils in RSV infection [20], following exposure to endotoxin [25] and in sarcoidosis [10], and therefore may be up-regulated in response to systemic inflammation. Here, ICAM1 is linked to sarcoidosis.