As a likely consequence of nodal and paranodal disruption, a significant switch from Nav1.6 to Nav1.2 expression occurs and both Nav1.2 and Nav1.6 immunoreactivities are diffusely distributed along extensive regions of demyelinated axons within acute MS plaques in human pathology (Craner et al., 2004) and in an EAE (Craner et al., 2003). Here, SCN2A is linked to myeloid sarcoma.