CNTNAP1 and Charcot-Marie-Tooth disease: In patients with hereditary neuropathies CMT (Charcot-Marie-Tooth disease), skin biopsy showed that Caspr immunostaining was spread from paranodes into both juxtaparanodes and internodes and Kv channels were distributed in patches along the internodal axolemma rather than remaining in juxtaparanodes (Li et al., 2005).