In post-mortem brains from individuals with bipolar disorder not exposed to antipsychotics, genes encoding ankyrinG, NrCAM, Nav1.6, KCNQ2, and βIV spectrin were significantly altered compared with the brains from bipolar disorder individuals exposed to antipsychotics or controls, suggesting a normalization effect of antipsychotics on the expression of these genes (Chen et al., 2013). Here, SCN8A is linked to bipolar disorder.