Together with the other results of the present study, this may suggest that intratumor injections of pRNAT-CMV3.2-Tie2 may silence the expression of Tie2, subsequently eliminate the tumor angiogenesis and metastasis pathway regulated by Tie2 and increase the efficiency of chemotherapy for endometrial carcinoma using carboplatin. This evidence concerns the gene TEK and endometrial carcinoma.