While we provide human and animal evidence for the protective role of SUCNR1 against dry AMD-like lesions, it is important to specify that the overall retinal degeneration observed in Sucnr1−/− is relatively mild when compared to the sever retinal degeneration reported in mutants of CCL-2 and CCR-2[17] or CX3CR1[18]. Here, CX3CR1 is linked to dry age related macular degeneration.