Secondly, since TGFβ protein expression is stimulated in tendinopathy [18,19] and pathway analysis following global gene expression profiling of chronic tendinopathic tendon tissue also showed an increase in genes related to TGFβ signalling, we were interested in the regulation of tenocyte gene expression by TGFβ. The gene discussed is TGFB1; the disease is disease of the tendon.