Effects of 5 weeks treatment with telmisartan (TELM) given either alone or combined with praziquantel (PZQ) on the mean granuloma diameter (μm), immunohistochemical expression of matrix metalloproteinase-2 (MMP-2) and tissue inhibitor of metalloproteinase-2 (TIMP-2) expressed as % of positively stained cells, and fibrotic area in μm2 and % of fibrotic area relative to the total area examined of mice infected with Schistosoma mansoni and sacrificed at the 10th (set 1) and 15th (set 2) weeks post infection. This evidence concerns the gene MMP2 and infection.