The study of molecular neurodegeneration largely focuses on the investigation of known neurotoxic insults that include Abeta peptides in Alzheimer’s Disease (AD), polyQ proteins in Huntington Disease (HD) and Ataxias, alpha-Synuclein in Parkinson’s Disease (PD), or tau tangles in tauopathies, to name but a few [5]. The gene discussed is MAPT; the disease is Alzheimer disease.