The objective of this study was to determine the roles of transforming growth factor β (TGFβ1), metalloproteinase-2 (MMP2), collagen αI (Collα1) and tissue inhibitor of metalloproteinase-1 (TIMP1) in preventing thioacetamide-induced liver cirrhosis in rats. The gene discussed is TGFB1; the disease is cirrhosis of liver.