TIMP1 and Hepatic fibrosis: These findings confirm the previous findings of Wills and Asha [21] who suggested that the hepatoprotective role of Lygodium flexuosum plant extract is because of the reduced mRNA levels of growth factors, proinflammatory cytokines, and other signaling molecules, which are involved in hepatic fibrosis including TGFβ1, procollagen-I, and TIMP1.