In the current study, we show that ATRA’s ability to induce MUC-2 expression in SW480 colon cancer cells might also involve CysLT2R signaling, as the effect can be reduced by either a CysLT2R inhibitor or by RARα siRNA alone or a combination of RARα and RARβ siRNA. Here, CYSLTR2 is linked to colonic neoplasm.