Therefore, it was hypothesized, in this article, that through imitating the high thyroid function or high endocrine hormone state of some choriocarcinoma patients during chemotherapy, the chemosensitivity may be enhanced by giving thyroid hormones or other endocrine hormones to the patient before and / or during chemotherapy, which may bring a new therapy to breast cancer and other malignant tumors. Here, TG is linked to choriocarcinoma.