Conversely, none of these measures were associated with stroke (Table 6), whereas both correlated with any lower limb vascular event (ulceration/gangrene and/or lower limb revascularization; Hb-A1c-SD only in Model 2) and HbA1c-SD alone with ulceration/gangrene (Table 7). The gene discussed is GSTM1; the disease is gangrene.