Initial or moderate increase of HIF-1α levels could lead to cell adaptation, and in the absence of oxygen cancer cells adjust to their new microenvironment mainly by angiogenesis stimulation by vascular endothelial growth factor (VEGF) [9], inhibition of apoptosis via Bcl-2 [10], modifying the cellular glucose/energy metabolism [11], adapting to acidic extracellular pH [12] and up-regulation of proteins involved in metastasis [13]. This evidence concerns the gene VEGFA and cancer.