In this study, we tested the effects of dyslipidemia-associated SNPs on the APOA1/C3/A5 gene cluster: APOA1 rs670, APOC3 rs2854116, APOC3 rs2854117, APOA5 rs662799 and APOA5 rs2075291 on breast cancer progression in a Taiwanese patient group with mainly operable early-stage tumors, and a 10-year follow-up interval. This evidence concerns the gene APOC3 and metabolic syndrome.