In addition, high CYCLON expression was significantly associated with high MYC expression in DLBCL of both the GCB and ABC subtypes, suggestive of co-selection of these two events in the pathogenesis of DLBCL (Fig 3C) (Lenz, p < 0.0001, Hummel, p = 0.0003). Here, CCDC86 is linked to diffuse large B-cell lymphoma.