This analysis revealed significant down-regulation by CYCLON knockdown of a proliferation gene expression signature that includes cancer testis antigens (e.g. MAGEA1, MAGEA3, MAGEA6, GAGE1), and that characterizes an aggressive subtype of multiple myeloma (Zhan et al, 2006) (Fig 4A and Supporting Information Table S3). This evidence concerns the gene CCDC86 and AL amyloidosis.