Although MYC gene alterations are implicated in this setting and are associated with poor outcome (Barrans et al, 2010; Cuccuini et al, 2012; Johnson et al, 2009; Savage et al, 2009; Visco et al, 2013), the specific effectors of MYC dependency in DLBCL are not well characterized (Aukema et al, 2011). Here, MYC is linked to diffuse large B-cell lymphoma.