In keeping with previous reports (Mertz et al, 2011), JQ1 treatment induced pronounced, dose-dependent MYC suppression in MYC-overexpressing lymphoma cells (Raji, B593, SUDHL4) while suppressive effects were more subtle in the lymphoma cell lines with lower starting levels of MYC (HT, OCI-Ly3 and Ly10) (Fig 6A). The gene discussed is MYC; the disease is lymphoma.