In keeping with this, CYCLON and JQ1 regulate a number of genes that encode factors of relevance to lymphoma B-cell survival, including the inhibitor of NFKB signalling, NFKBIA as well as JNK1, known to be involved in complement-mediated cytotoxicity (Gancz et al, 2009; Jeon et al, 2009). Here, MAPK8 is linked to lymphoma.