MACROH2A1 and melanoma: CYCLON is a novel, cytokine-inducible, nuclear phosphoprotein (Hoshino & Fujii, 2007) that bears a coiled coil domain, also shared with many transcription factors, whereas H2AFY encodes a histone variant that has been shown to influence prognosis in malignant melanoma and lung cancer (Kapoor et al, 2010; Sporn et al, 2009).