ASCL1 and nervous system disorder: In neurological diseases that are connected to the incapacity of neurons to self-renew (reviewed in Rouaux et al, 2012) reprogrammed neurons were obtained by expression of Ascl1, Brn1 and Myt1l (Pang et al, 2011; Vierbuchen et al, 2010) and dopamine-producing neurons were produced by transfecting human and mouse fibroblasts with a set of three transcription factors (MASH1, NURR1 and LMX1a), with remarkable implications for the treatment of Parkinson's disease (Caiazzo et al, 2011).