CFLAR and Hypoinsulinemia: To assess the role of cFLIP in hepatocytes during STZ-induced hypoinsulinemia, we used mice exhibiting a hepatocyte-specific deletion of cFLIP using the cre-loxP system under control of the albumin promoter (flip−/−) and compared these with cre-negative control mice (wild-type (wt)).5 STZ treatment resulted in hyperglycemia independent of the underlying genotype (Figure 1b).