Moreover, in high concentrations, acute toxicity in extrapancreatic organs has been described.18 To assess the effect of hypoinsulinemia induced by repetitive low-dose STZ treatment on the expression of cFLIP, C57Bl/6 mice received 80 μg/g STZ or solvent (intraperitoneally) over 5 days. The gene discussed is CFLAR; the disease is Hypoinsulinemia.