CASP3 and meningioma: This observation is consistent with the effects of LPVs on meningioma cells as they block proliferation through cell cycle inhibition in an AKT-independent manner without induction of apoptosis.42 Conversely, our results showed that LPV induced apoptosis efficiently in Oct-4-positive CSCs, as measured by CASP3 activation and PARP-1 cleavage.