DMD and neuromuscular disease caused by qualitative or quantitative defects of dystrophin: This is an interesting finding from a global analysis of protein expression patterns in dystrophinopathy and agrees with the idea that the loss of dystrophin and concomitant reduction of associated glycoproteins results in considerably different secondary changes and cellular adaptations in individual skeletal muscles, despite the fact that all contractile mdx tissues exhibit the same primary genetic abnormality.