The transplantation of Lewis X (LeX) and CXCR4 (Le+/CX+) NPCs into superoxide dismutase (SOD)1-G93A transgenic mice, as a model of amyotrophic lateral sclerosis (ALS), led to neuroprotection that correlated with increased spinal cord levels of VEGF and IGF-1 [99]. The gene discussed is IGF1; the disease is amyotrophic lateral sclerosis.