The intrastriatal injection of human umbilical cord mesenchymal stem cells (HUMSC) modified to overexpress VEGF led to a significant reduction of apomorphine-induced rotations, and a revival of tyrosine hydroxylase (TH) immunoreactivity at the level of the lesioned striatum and substantia nigra in rotenone-induced experimental chronic PD rats [160]. The gene discussed is TH; the disease is Parkinson disease.