HSPG2 and migraine disorder: Migraine model studies further implicate PLC pathway involvement: the migraine trigger pituitary adenylate cyclase activating peptide-38 induced mast cell degranulation in the rat dura mater, mediated by the PLC pathway [29]; and a homolog of the familial hemiplegic migraine candidate gene 2 in C. elegans (EAT-6) interacts with a homolog (EGL-8) of PLC [30].