In a multivariable analysis of migraineurs that considered sex, number of medications used, migraine frequency (days) in the past year, psychiatric measures, and number of comorbidities as potential predictors of PC-PLC activity, only number of comorbidities was independently significantly related to PC-PLC (parameter estimate (SE) = 1.77 (0.58), p = 0.009; Table 3). The gene discussed is HSPG2; the disease is migraine disorder.