Similar to other previous reports of China [10,14,26], our study showed that GJB2 mutations were an important cause of NSHL in Jiangsu deafness populations, and the most common GJB2 mutation detected in our study group was the c.235delC (102/658; 15.50% ). The gene discussed is GJB2; the disease is nodular sclerosis classical Hodgkin lymphoma.