The first one, represented by female V006 showed moderate but widespread Hes1 expression (Figure 6J), moderate estrogen receptor staining (Figure 6K), undetectable p63 expression (Figure 6L), normal E-cadherin distribution (Figure 6M), and a marked up-regulation of Ki67 and Hey1 expression (Figure 6N, O) in the tumor area. This evidence concerns the gene HES1 and neoplasm.