HAT1 and colonic neoplasm: A very similar result is obtained when bi-clustering over only HCT116 and SW480 (two colon cancer cell lines clustered together in Figure 1), where over an eight-fold increase in the H4 HATs CDY1 and HAT1 is observed (Additional file 5), and notably HCT116 is found to be enriched in H4 acetylation (Figure 4).