BRD4 and cancer: One example linking cancer with a histone PTM-binding protein includes associations between bromodomain-containing BRD3 and BRD4 proteins, which recognizes histones H4 acetylated at K5, K8 and K12 [6], and PAFc and SEC elongation factors in MLL fusion leukemias [7], as well as translational fusions between BRD4 and NUT proteins in certain squamous carcinomas [8,9].