A very similar result is obtained when bi-clustering over only HCT116 and SW480 (two colon cancer cell lines clustered together in Figure 1), where over an eight-fold increase in the H4 HATs CDY1 and HAT1 is observed (Additional file 5), and notably HCT116 is found to be enriched in H4 acetylation (Figure 4). Here, HAT1 is linked to malignant colon neoplasm.