CFTR and vibrio infectious disease: This observation, together with the inhibitory effect of CFTRinh-172 on V. cholerae-induced intestinal fluid secretion, suggests that CFTR-mediated Cl− secretion is the major pathophysiological event leading to secretory diarrhea at least in the early phase (∼12 h) of V. cholerae infection and could be the important target of anti-secretory drug for cholera.