Above all, GBM is difficult to treat using the conventional therapeutic options of standard surgical resection, radiation and chemotherapy, owing to its high frequency of recurrence [2], as well as is related to the upregulation of Bcl-w [3], MMP-2 (matrix metalloproteinase-2) [4–7] and β-catenin [8]. The gene discussed is MMP2; the disease is glioblastoma.