To confirm these data, transfection of U251 glioblastoma cells with Bcl-w-targeted siRNA significantly suppressed expression of the mesenchymal markers, Twist1, Snail, Slug and vimentin (Figure 1C), and reduced invasive ability via inhibition of MMP-2 production (Figure 6A). The gene discussed is SNAI2; the disease is glioblastoma.