Furthermore, diabetes resulted in elevated levels of total ROCK I and ROCK II as well as phosphorylated levels of ROCK II at Y256 (note at the time of peforming this study no phospho-specific antibody for detecting ROCK 1 was available) and ERK1/2 in the mesenteric vascular bed that could be significantly attenuated by chronic AG825 treatment (Figure 3a). Here, MAPK3 is linked to diabetes mellitus.