MAPK3 and diabetes mellitus: To confirm the role of ROCK and ERK1/2 as mediators of diabetes-induced vascular dysfunction, we next hypothesized that blockade of ROCK signaling via fasudil, or ERK1/2 signaling by PD 98059 should correct the hyper-reactivity of the diabetic mesenteric vascular bed to NE (Figures 6 and 7).