Indeed, we have previously shown in a rat model of type 1 diabetes that EGFR levels are raised in the diabetic vasculature and chronic inhibition of EGFR with the selective receptor antagonist AG1478, prevented the development of diabetes-induced abnormal vascular reactivity in the mesenteric vascular bed and renal artery [16]–[18]. The gene discussed is EGFR; the disease is type 1 diabetes mellitus.