MAPK3 and diabetes mellitus: The fact that acute treatment of the diabetic mesenteric bed vasculature with AG825 also led to effective inhibition of diabetes-induced elevation in ErbB2, ROCK and ERK1/2 phosphorylation (Figure 3B) as well as correction of the altered vascular reactivity to NE and carbachol (Figure 1) not only supported our hypothesis further but also implied that ErbB2 blockade might be effective in both a preventative (chronic administration) or short-term (acute) treatment strategy in diabetes-induced vascular dysfunction.