The possibility that Ang II might be an upstream effector of ErbB2 signaling is supported by the fact that Ang II, rather like erbB2 in this study, can also upregulate ERKs and ROCK - a regulator of diverse vascular functions including smooth muscle contraction, cell migration and adhesion, and cell inflammatory responses all of which may be involved in vascular dysfunction such as atherosclerosis [23], [43]–[44]. The gene discussed is AGT; the disease is atherosclerosis.