INS and Hyperglycemia: We extended our endotoxemia results using the cecal ligation and puncture (CLP) model of sepsis, though we were unable to perform the FSIVGTT in these animals as they exhibit profound hyperglycemia in the setting of glucose infusion (beyond the level of detection of our glucometer) precluding the generation of meaningful glucose and insulin disposal curves necessary for modeling of the FSIVGTT.