In 2001, gene expression profiling revealed, among others, fibromodulin (FMOD) as one of the most overexpressed genes in CLL compared to memory B cells of healthy donors.[1] FMOD is a member of the small leucine-rich proteoglycan family (SLRP) and is normally expressed in collagen-rich tissues. The gene discussed is FMOD; the disease is B-cell chronic lymphocytic leukemia.