BIN1 and centronuclear myopathy: Using Sanger sequencing, the patients were previously excluded for several genes implicated in nemaline or centronuclear myopathies, including ACTA1, TPM2, TPM3, TNNT1 for families 1 and 2, MTM1 and BIN1 for families 3 to 6, and DNM2 for families 3, 4 and 6.