Hypothetically, the associated insulin resistance, compensatory hyperinsulinemia and increased insulin like growth factor in type 2 diabetes inhibit hepatic synthesis of sex hormone binding globulin (SHBG), stimulate ovarian synthesis of sex steroid, and consequently promote cellular proliferation and inhibition of apoptosis of breast and endometrial epithelium [35]. This evidence concerns the gene SHBG and type 2 diabetes mellitus.