Application to Breast Cancer: We applied our tested approaches to build informative priors for a sub-sample of the well known breast cancer microarray data set by van't Veer et al.[37] contained in catnet. The data consists of 1214 genes for 98 patient samples: 34 patients developed distant metastases within 5 years, 44 patients remained disease-free after a period of at least 5 years, 18 patients had BRCA1 germline mutations, and 2 were BRCA2 carriers. This evidence concerns the gene BRCA2 and breast carcinoma.