APOE and Alzheimer disease: Additionally, we will elucidate the effects of the genetic status (e.g. Apolipoprotein E (APOE)) on the longitudinal changes in BrainAGE as well as on prediction of AD conversion, since especially the APOE ε4 allele is associated with modification of cognitive functioning [69]–[71] and GM reduction in AD patients [72] as well as healthy subjects [73].