Using as a model LNCaP prostate cancer cells subject to specific RNAi depletion for PKCα, PKCδ, and PKCε (the main DAG/phorbol ester-responsive PKCs expressed in these cells), this microarray analysis revealed that PKC isozymes exhibit both overlapping and selective roles in the control of gene expression, as one would anticipate from their distinctive functional properties. This evidence concerns the gene PRKCD and Familial prostate cancer.