Compared with the GG genotype, the GA, AA and GA+AA genotypes for UCP2 rs659366 were not associated with CRC risk (OR = 0.839, 95% CI 0.610–1.152; OR = 1.047, 95% CI 0.682–1.609; and OR = 0.888, 95% CI 0.658–1.197, respectively). This evidence concerns the gene UCP2 and colorectal carcinoma.