In livers of ADOX OB animals at 10 days p.t. (Figure 6F), the very high levels of lipid accumulation due to the obesity of these animals were reduced by over-expression of Ildr2. In association with this reduction, levels of transcripts related to neutral lipid synthesis and cholesterol are increased, suggesting “relief” of the secondary suppression imposed by lipid accumulation as mentioned above [25]. This evidence concerns the gene ILDR2 and obesity due to melanocortin 4 receptor deficiency.