Similarly, Kaplan-Meier analysis proved that patients with positive serum XAF1 methylation had significantly lower DFS than that in the patients without serum XAF1 methylation (p<0.0001) (Figure 7B), indicating that XAF1 promoter methylation in serum was an unfavorable predictor for the gastric cancer patients. This evidence concerns the gene XAF1 and gastric cancer.