The regression model to predict MCS in the total sample explained 14.6% of the variance with main effects of age, ethnicity, secondary education, higher income, insulin, stroke, asthma/lung diseases, musculoskeletal conditions, medication, smoking, physical energy expenditure and family functioning emerging as significant determinants, and as well as interaction terms of insulin and high density lipoprotein cholesterol by ethnicity in the final MCS model (Table 4). The gene discussed is INS; the disease is lung disorder.