To investigate the cellular function of RPS27L, we infected LoVo cells, a wild-type p53-expressing cell line from a stage at stage III CRC, using a lentivirus-mediated short hairpin RNA (shRNA) to efficiently knock down RPS27L expression (shRPS27L) or a control shRNA (shLuc) (Figure S1). Here, TP53 is linked to colorectal carcinoma.