CCR2, FNDC3B, GMNN, HERC5, IFI6, IFIT3, IFITM1, LAP3, MX1, NKG7, OAS3, PLSCR1, SPCS3, STAT1 were all up-regulated by at least 4-fold in active SLE B cells. The gene discussed is SPCS3; the disease is systemic lupus erythematosus.