Deletion of C6L in the vector backbone of the HIV/AIDS vaccine candidate MVA-B, enhanced HIV-1–specific cellular and humoral immune responses following a DNA prime/MVA boost immunization protocol in mice, and induced an up-regulation of the expression of IFN-β and IFN-α/β-inducible genes in human macrophages and monocyte-derived dendritic cells (moDCs) [15]. This evidence concerns the gene IFNA1 and AIDS.