All 26 positive serum samples from spontaneous clearance group and CHC group were tested for their ability to neutralize HCVpp bearing the envelope glycoproteins of genotypes 1a, 1b, 2a, 3a, 4, 5 and 6.Six serum sampleswere found to have cross-genotype neutralizing capacity. Here, ERVW-1 is linked to cryohydrocytosis.