ADIPOQ and Insulin resistance: Datsani and colleagues recently showed convincing evidence of association between a multiple SNP adiponectin-decreasing gene score and decreased body mass index (BMI), increased waist to hip ratio (WHR), higher triglyceride (TG) levels, lower HDL-C concentrations, higher post oral glucose tolerance test (OGTT) 2-hr glucose level, higher homeostatic model assessment-insulin resistance (HOMA-IR) and increased T2D risk using large datasets from international consortia [25].