CCND1 and hepatocellular carcinoma: Importantly, a role of miR-338-3p in tumorigenesis has been previously suggested, as miR-338-3p is down regulated in rectal cancer [19], and is regulated by Hepatitis B virus X protein (HBx) to inhibit proliferation and invasion of hepatoma cells by binding to target genes CyclinD1 and smoothened in hepatocellular carcinoma [20]–[22].