RXRA and Familial prostate cancer: Other genes with polymorphisms significantly associated with pancreas cancer risk included LRP2, CASR, and RXRA. The LRP2 (megalin) gene is involved in cell uptake of vitamins [28], including vitamin D, and variants in LRP2 have previously been associated with prostate cancer risk [29]; although this mechanism may be due to modified uptake of androgens [29].